Autor: Andreas Teufel

The central project 1 will support the GenoMiCC research unit by providing central metabolomics services, chemical libraries, and support with microbiome-specific animal models. By improving standardisation, developing more sensitive and quantitative analytical methods, and fostering larger collaborative studies, this central project aims to enhance the reproducibility and clinical relevance of microbiome and metabolomics findings in …

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S. Schürle and A. Schubert will use genome engineering with the aim to provide mechanistic insights into signalling pathways in the tumour–microbe–drug interplay. For this, they will utilise and optimise existing organ-on-a-chip models of CRC that mimic physiologically relevant biochemical and physical cues of tumour and metastatic niches. The system provides means to perform multiparametric …

Mehr über „Project 8: Schürrle/Schubert – Bacterial engineering, functional genomics“ Lesen

J. Betge and J. Schott hypothesise that specific microbial metabolites affect translation control and thereby plasticity and drug resistance in CRC, mediated by mTOR-dependent and -independent mechanisms. In P7 J. Betge and J. Schott will analyse the activity and heterogeneity of central regulators of translation in PDOs and mouse tumours upon treatment with standard-of-care drugs …

Mehr über „Project 7: Schott/Betge – Translational control, microbiome, therapy resistance“ Lesen

M. Boutros and M. Ebert are interested in the impact of microbial-derived metabolites on tumor progression and treatment response with a focus on Wnt and MAPK signaling. They will utilize a large biobank of patient-derived organoids and perform genetic, transcriptomic and phenotypic profiling to facilitate insights in metabolite- oncogenic signaling-therapy response axis n CRC progression …

Mehr über „Project 5: Boutros/Ebert – Microbial metabolites and oncogenic signaling“ Lesen