Prof. Dr. Patrick Schloss
Deutsche ilco –Self-help association for ostomy patients and people with colorectal cancer, as well as their relatives Stuttgart, Germany
Prof. Dr. Jürgen Riemann
Prof. Jürgen F. Riemann, MDChairman of the Board, Stiftung LebensBlicke – Foundation for the Early Detection of Colorectal CancerFormer Director, Department of Medicine CKlinikum Ludwigshafen am RheinLudwigshafen, Germany
Prof. Dr. Christoph Röcken
Prof. Dr. Christoph Röcken Director, Institute of PathologyUniversity Medical Center Schleswig-Holstein (UKSH), Campus KielChristian-Albrechts-University of KielKiel, Germany.
Prof. Dr. Yun Ju
Prof. Jun Yu, MD, PhDChoh-Ming Li Professor of Medicine & TherapeuticsAssistant Dean (Mainland Affairs), Faculty of MedicineDirector, Institute of Digestive DiseaseDirector, State Key Laboratory of Digestive DiseaseDepartment of Medicine and TherapeuticsThe Chinese University of Hong Kong (CUHK)Prince of Wales HospitalShatin, New TerritoriesHong Kong SAR, China
Prof. Dr. Diether Lambrechts
Prof. Diether Lambrechts, PhDHead of the Laboratory of Translational Genetics (VIB-KU Leuven)Full Professor, Department of Human Genetics, KU Leuven, BelgiumScience Director, VIB‑KU Leuven Center for Cancer Biology
Central Project 2: Data Management, Integration and Analysis
Central project 2 will provide data management expertise to all members of the consortium, unify data collection and analysis pipelines, and ensure sustainable use of all research data acquired during the project. It will provide support to unify data and metadata collection protocols, as well as data management plans across the projects to streamline sharing …
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Central Project 1: Functional Microbiomics and Metabolomics Research
The central project 1 will support the GenoMiCC research unit by providing central metabolomics services, chemical libraries, and support with microbiome-specific animal models. By improving standardisation, developing more sensitive and quantitative analytical methods, and fostering larger collaborative studies, this central project aims to enhance the reproducibility and clinical relevance of microbiome and metabolomics findings in …
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Dr. Nadja Meindl-Beinker,PD
PD Dr. Nadja Meindl‑Beinker is a senior researcher at Heidelberg University’s Medical Faculty Mannheim in the Molecular Hepatology department. Since 2010, her work has centered on transforming growth factor‑β (TGF‑β) signaling and its complex roles in chronic liver disease and hepatocellular carcinoma . She earned her doctorate (Dr. rer. nat.) and completed postdoctoral research at Ruhr University …
Project 8: Schürrle/Schubert – Bacterial engineering, functional genomics
S. Schürle and A. Schubert will use genome engineering with the aim to provide mechanistic insights into signalling pathways in the tumour–microbe–drug interplay. For this, they will utilise and optimise existing organ-on-a-chip models of CRC that mimic physiologically relevant biochemical and physical cues of tumour and metastatic niches. The system provides means to perform multiparametric …
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Project 7: Schott/Betge – Translational control, microbiome, therapy resistance
J. Betge and J. Schott hypothesise that specific microbial metabolites affect translation control and thereby plasticity and drug resistance in CRC, mediated by mTOR-dependent and -independent mechanisms. In P7 J. Betge and J. Schott will analyse the activity and heterogeneity of central regulators of translation in PDOs and mouse tumours upon treatment with standard-of-care drugs …
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