Project 2: Burgermeister/Zeller – Tumor resident microbiota

E. Burgermeister and G. Zeller will build on these spatial studies to reconstitute the key associations discovered in situ using PDO models from primary CRC tumours and metastases. This shall enable mechanistic dissection of microbe-host crosstalk and its impact on the efficacies of chemo- and targeted therapies, paving the way for future microbiome-aware personalised oncology approaches to prevent treatment resistance in metastatic CRC.