Dr. Johanna Schott

Dr. Johanna Daniela Schott is a research professor in Biochemistry at Heidelberg University’s Mannheim Institute for Innate Immunoscience (MI³) and a project group leader within Georg Stoecklin’s lab at the Medical Faculty Mannheim. Her work investigates the rapid dynamics of gene expression in innate immune cells, focusing on mRNA processing, translation, and decay during inflammatory responses. By combining experimental approaches with bioinformatics and statistical modeling, she explores how post-transcriptional regulation shapes immune function.

Dr. Schott earned her doctorate (Dr. rer. nat.) and has authored influential research on translational control in macrophages, ribosome profiling (Ribo-Seq), and bioinformatics tool development. Her notable publications include a 2021 Nature Methods paper employing nascent Ribo-Seq to reveal ribosomal loading times, as well as studies on inflammatory translational regulation and mechanisms of mRNA decay in immune signaling.

More recently, she contributed to a study published in EMBO Journal (2023) exploring the role of queuosine-modified tRNAs in sex-dependent learning and memory in mice, underscoring her versatility in applying molecular and computational analyses to both immunology and neuroscience.

In her current role, Dr. Schott leads a team that develops novel experimental and computational methods to dissect post-transcriptional regulation in macrophage and innate immune responses. Her interdisciplinary expertise spans molecular biology, high-throughput sequencing, translational regulation, and statistical modeling.